DOI: 10.36347/sjams.2020.v08i11.026

Pages: 2562-2565

Objective: In this study our main goal is to evaluate the CD4 and CD8 count in breast cancer patient undergoing post-Surgery FAC protocol. Method: This quasi-experimental study was carried out at Dept. of Microbiology, Department of radiotherapy & Department of Surgery, Sylhet MAG Osmani Medical College Hospital from January, 01, 2011 to December, 31, 2011. Samples from the 30 cases were collected, first from Department of surgery (before operative procedure) and then, from Department of radiotherapy (after surgery and 3 cycles of adjuvant chemotherapy) from the same patient. Results: During the study, left breast was involved in 17 (53.3%) patients and right breast was involved in 13 (43.3%) patients. Regarding histological grading was grade-II in 13 (43.3%) cases, grade-I in 11 (37.7%) and grade-III in 6 (20.0%) cases.CD4+T cell count before chemotherapy was 1023.4 /uL (SD ± 320.7) and CD4+T cell count after chemotherapy was 540.7 /uL (SD ± 266.1). CD4+T cell count was significantly reduced after chemotherapy (z=9.164; p<0.001). Conclusion: from our study we conclude that, CD4 and CD8+ T cell number and their ratio as an assessment of immune function status in breast cancer patients, before and after surgery and adjuvant chemotherapy with the intention of delineating any potential immune aberrations that may result from therapy.