DOI: 10.36347/sasjm.2015.v01i01.003

Pages: Page: 16-21

The present study was designed to investigate the cytotoxic and thrombolytic activity of methanolic extract of fruits of Citrus macroptera. Methanolic extract of Citrus macroptera, was used to evaluate its cytotoxicity in Brine shrimp lethality bioassay where vincristinsulphate was used as standard drug. Thrombolytic effect of the fraction was investigated in clot lysis experiment. In Brine shrimp lethality bioassay, LC50 value of the extract was 30.90μg/ml and vincristinsulphate served as the positive control showed LC50 value 10.51 μg/ml. The extract exerted 48.47%lysis of the blood clot in thrombolytic activity test while 75.18% and 15.82% lysis were obtained for positive control (streptokinase) and negative control respectively. Compared to vincristinsulphate, it is evident that the methanolic extract of fruits of Citrus macropterawas cytotoxic. So, the extract possessed considerable thrombolytic activity. Which compounds is responsible for the present pharmacological actions and to know their mechanism of action, extensive pharmacological and phytochemical experiments are essential