DOI: 10.36347/sjams.2020.v08i11.040

Pages: 2620-2624

Differential diagnosis of thrombocytopenia can be assessed by studying variation of platelet indices. Different platelet indices such as MPV, PDW, P-LCR, Plateletcrit can be used for these purposes. A study of 200 cases of thrombocytopenia were conducted, corroborated there causes with different platelet indices. It was observed that in the hyper-destructive group (viz. due to infective causes, ITP and SLE), MPV, PDW and P-LCR showed an inverse correlation with the platelet count. Whereas, in the hypo-productive group (viz. due to aplastic anaemia, megaloblastic anaemia, and acute leukaemia and drug-induced) and in control group all the parameters showed a direct correlation to their respective platelet counts. However, bone marrow is the gold standard to differentiate between hypo-productive and hyper-destructive thrombocytopenia, it is agreed that more elaborate and controlled studies are needed to ascertain the importance of these readily available platelet indices in term of their sensitivity, specificity, positive and negative predictive values to get a proper idea about the underlying patho-mechanism of thrombocytopenia. These parameters are to be viewed as a guide to understand the basic patho-mechanisms of thrombocytopenia.