DOI: 10.36347/sajp.2020.v09i12.002

Pages: 336-339

Photopharmacology means use of light to precisely drug deliver at target site. Such a novel methods ability to improve drug specificity by reducing off-target effects. The energy of light is used to change for shape and chemical properties of the drug, resulting in different mechanism of action of drug. This is done to eventually to get control when and where drugs are active in a reversible manner, to prevent side effects, Adverse effects, and toxicity. It aims to reduce systemic toxicity of drug and the emergence of resistance, while attaining unprecedented correctness in treatment. Azobenzenes, the little photoswitches that could’ - very reliable little engines with which to drive things.” The steadier trans isomer has the benzene rings on reverse sides but, on radioactivity with ultraviolet (UV) light, this switches to the cis verification, with the benzene rings sitting next to each other. Azobenzenes also advantage from being a large pre-existing list of toxicity data owing to their extensive industrial use. A novel drug Glimethoride is a third-generation sulfonylurea, consist of an azobenzene unit. The drug activated after a meal, most probable using an implanted blue LED: “The drug switches on very rapidly in milliseconds, and because it switches off within about two seconds and able to get quite fine control. Photopharmacology could also be used to target antibiotic resistance. It has been novel research in the field, has decades of knowledge in designing molecular switches for nanoelectronics and saw a prospect to try some of that experience to the problem of antibiotic resistance.