DOI: 10.36347/sjams.2020.v08i12.016

Pages: 2768-2771

Introduction: The incidence of oesophageal carcinoma is increasing in the world as well as in Bangladesh. Aim of the Study: The aim of the present study was to assess the efficacy and safety of paclitaxel-capecitabine based sequential chemoradiotherapy for advanced inoperable oesophageal cancer. Material & Methods: This prospective analytical study was conducted in the Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh and in the Department of Radiation oncology and Department of Radiotherapy, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh from July 2016 to June 2017. Forty (40) patients with locally advanced carcinoma of the oesophagus (stage IIB – stage IVA) treated with sequential chemo radiation were enrolled in this study. They were treated with Paclitaxel and Capecitabine followed by radiotherapy. Results: Final follow up was done at 6 month (24 weeks) after completion of treatment and it was observed that 72.5% had clinical response. Conclusion: Sequential chemo radiation with Paclitaxel-Capecitabine is an effective, tolerable and convenient regime in the treatment of locally advanced carcinoma oesophagus.