DOI: 10.36347/sjams.2020.v08i12.018

Pages: 2777-2782

Background: Antimicrobial resistance is one of the major public health emergencies worldwide, and this trend didn’t spare developing countries like Bangladesh. Objective: To Evaluate The Blood Culture Profile And Antimicrobial Resistance Pattern: A Study In Intensive Care Unit (ICU) Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh. Methods: A hospital based observational study was conducted from April 2018 to May 2019 in Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh. A total of 303 neonates with clinical sepsis were included. Collected data were entered into EPI-INFO version 6.04(CDC, Atlanta, GA) for cleanup; and then exported to SPSS version 21.0 for further analysis. Frequencies and proportion were used to describe the study population in relation to relevant variables. Results: Bacterial growth was detected in 88 (29.4%) of blood cultures. Predominantly isolated bacteria were coagulase negative staphylococci (CoNS) 22 (25%), Escherichia coli (E.Coli) 18 (20.5%) and Staphylococcus aureus 16 (18%). Resistance rates of S. aureus and CoNS against Ampicillin were 11 (69%) and 20 (91%) respectively. The resistance rate of E. coli against Ampicillin and Gentamycin were 12 (66.7%) and 10 (55.6%) while Klebsiella spp. resistance rate gets much higher against these two first line antibiotics [10 (91%) and 9 (82%) respectively]. Similarly, both Gram positive and Gram negative bacteria isolates were also highly resistant to third generation Cephalosporins, and 63 (72%) isolated bacteria showed multidrug-resistance. However; Gram-positive bacteria isolates had better susceptibility patterns to third line antibiotics like Clindamycin, Vancomycin and Ciprofloxacin while Gram-negative isolates had a higher susceptibility to Ciprofloxacin and Amikacin. Conclusion: CoNS, S. aureus, E. coli and Klebsiella spp. were the leading bacterial causes of neonatal sepsis in our study. They were highly resistant to first- and second-line empiric antimicrobial treatment used .......