DOI: 10.36347/sjams.2020.v08i12.026

Pages: 2818-2820

Context: Beta thalassemia trait (beta-TT) is common among Indian population especially among communities like Sindhis, Bengalis and Gujaratis (Lohanas). Individuals having beta-TT have mild Microcytic Hypochromic Anemia (MCHCA) and asymptomatic course same as that of Iron Deficiency Anemia (IDA). The aim of our study is to evaluate the reliability of Mentzer index as a screening tool in diagnosis of beta-TT and differentiate between other causes of MCHCA. Aim: To study the reliability of Mentzer index as a screening tool for diagnosis of beta thalassemia trait. Methods and Material: The data were taken from 100 patients of Microcytic Hypochromic Anemia at Green Cross laboratory, C. U. Shah Medical College and Hospital, who underwent CBC (Complete Blood Count) and Hb electrophoresis. Statistical analysis used: Sensitivity, Specificity, Positive predictive value (PPV), Negative predictive value (NPV). Results: The blood samples of 100 patients (Age: 0-26 years), who are included in the study, were run through a 5-part cell counter which revealed Hb, PCV, MCV and RDW of each sample. The peripheral smear examination of the samples revealed the finding of Microcytic Hypochromic Anemia. All 100 blood samples then studied for Hb electrophoresis. Out of 100 patients 58 patients had Mentzer index <13, out of which 43 patients were diagnosed with beta thalassemia trait by Hb electrophoresi (Hb A2 >3.5%). Conclusions: Mentzer index is a reliable screening tool for diagnosis of beta-TT and it can be used as a screening tool at small setups and at peripheral areas where Hb electrophoresis is not readily available.