DOI: 10.36347/sjams.2020.v08i12.029

Pages: 2834-2839

Introduction: Eclampsia is important cause of maternal mortality during pregnancy, child birth and puerperium. It accounts for (16%) of maternal mortality and still regarded as one of the leading cause of maternal death. In Bangladesh, eclampsia is the 3rd major cause of maternal death. Magnesium sulfate is now the drug of choice for women with eclampsia for controlling convulsion with strong evidence that it is better than diazepam, phenytoin or lytic cocktail. Objective: To compare the effect of 'loading' dose of magnesium sulfate with that of 'traditional' dose for control of convulsion in eclampsia. Methods: Prospective comparative study. In the Department of Obstetrics and Gynaecology, Rajshahi Medical College Hospital (RMCH)" from January 08 to December, 08 Ectamptic patients with gestational periods beyond 28 weeks. A total of 100 eclamptic patients who are eligible for magnesium sulfate therapy were purposively assigned to receive either only loading "dose or traditional dose for control of convulsion. Data was organized and the results were presented in tables, figures, diagram etc by using SPSS-10 and MS-Excel 2016. Continuous variables between groups were compared by using the unpaired’t’ test and chi-square test and 'P' Value less than 0.05 were considered statistically significant. Results: It shows that there is no significant difference between the two groups in terms of patient's profile, physical findings, distribution of convulsion along with recurrence, feto-maternal out come and regarding the toxicity of magnesium sulfate. Conclusion: The present study shows that only loading dose has some advantage over traditional dose because once loading dose is administered frequent monitoring of the patient is not necessary. So manpower involvement is less. As single loading dose can effectively control and prevent recurrent convulsion, so no extra cost" is required for extra MgSO4. For the above reasons eclampsia can be treated effectively by only loading