DOI: 10.36347/sjmcr.2020.v08i12.013

Pages: 1037-1041

Uterine cervical cancer is the commonest form of gynecologic malignancy in Bangladesh and South east Asia. The aim of this study was to compare the treatment outcome and complications following treatment with 9 Gy (gray) in two fractions of intracavitery radiotherapy (ICRT) following external beam radiotherapy (EBRT) with 7 Gy in three fractions of ICRT. A prospective randomized study carried out in different tertiary hospitals of Bangladesh during the period of 2015 to 2016 with a number of 61 patients evaluated, all patients received EBRT 50 Gy in 25 fraction of 2Gy per fraction over a period of 5 weeks and inj. Cisplatin 40 mg/m² weekly. Then ICRT weekly two fractions with 9 Gy per fraction in arm A and three fractions of 7 Gy to arm B was delivered. At 3 years follow up, complete remission was 77% and 73% respectively for arm A and arm B. The overall complete response was 75%. The common toxicities associated with treatment were bladder and rectal toxicities, skin reaction and hematologic complications which were managed well. During follow up after 3 years, there was no grade 3 or 4 toxicities and rectal and bladder toxicities were similar in both arms. This study showed that after standard EBRT total dose of 18 Gy ICRT in two fractions of 9 Gy over 2 weeks is equally effective in local control with acceptable toxicities in comparison with a total dose of 21 Gy in three fractions of 7 Gy ICRT.