DOI: 10.36347/sjams.2020.v08i12.035

Pages: 2865-2873

Introduction: Sepsis is one of the oldest and most elusive syndromes in Medicine. The clinical manifestations of sepsis are highly variable, depending on the initial site of infection, the causative organism, the pattern of acute organ dysfunction, the underlying health status of the patient, and the interval before initiation of treatment. Aim of this study: To observe the clinical and laboratory profile of patients with sepsis & severe sepsis as well as hospital mortality at the end of the 1st week. Method: It was hospital based cross sectional, observational study and was carried out in the Department of Medicine, Dhaka Medical College Hospital (DMCH) during the period of January 2015 to December 2015.Patients admitted in the intensive care unit (ICU) of DMCH, who fulfilled the criteria of sepsis or severe sepsis and aged more than 14 Years, among them 100 patients were enrolled in the study. Data from each patient was collected in structured data sheets. Finally, all data compiled and statistical analysis was carried out by using IBM SPSS Statistics 22.0 (IBM Inc, Chicago, Illinois, USA). Result: Among 100 patients, 35% were in sepsis group and 65% were in severe sepsis group. Fever was present in 97.1% cases, Heart rate > 90 beats/min in 82.9%, Tachypnea in 37.1%, edema 5.7%, Hyperglycemia in 25.7%, Arterial hypoxemia in 22.9%, Leukocytosis in 88.65% and Plasma C-reactive protein was 94.3%.Sepsis induced arterial hypotension was 40%, Hyperlactataemia was 44.6%, Acute oliguria was 18.5%, Acute lung injury with Pao2/Fio2 < 200 in the presence of pneumonia as infection source was 16.9%, Creatinine > 2.0 mg/dL was 23.1%, Serum bilirubin > 2 mg/dL was in 7.7%, Thrombocytopenia was 38.5% and Coagulopathy was 21.5%. Correlation of GCS score at seventh day with initial AMT score appeared to be particularly strong (Rs = 0.663, P<0.001). Blood Culture was positive in 8.2% only. Whereas Throat Swab culture is positive in 83.3% cases. Systemic hypotension (P=0.004), ......