DOI: 10.36347/sjams.2020.v08i12.039

Pages: 2890-2896

Background: In recent times the treatment of enteric fever is becoming more and more difficult. The aim of our study was to find out a cost effective way of treatment of enteric fever and to determine the success rate & fever clearance time of ceftriaxone as monotherapy in comparison to combinations of cefixime plus azithromycin. Method: Randomized single blind controlled comparative experimental study carried out in the Department of Medicine, Uttara Adhunik Medical College & Hospital, and Dhaka, Bangladesh during the period from 1st September, 2015 to 1st September, 2015. A total 96 cases of enteric fever patients were included based on inclusion and exclusion criteria. After taking informed written consent data was collected by a questionnaire and relevant investigations were done. Control group were given inj ceftriaxone and experimental group were given cefixime plus azithromycin. Then collected data was analyzed. Main Outcome measures: Age, Sex, response of treatment of Fever, Myalgia, Headache, Anorexia, Constipation, Diarrhoea, Abdominal pain, Cough, Relative bradycardia, Rose spot on trunk, Splenomegaly, Hepatomegaly, Coated tongue and treatment failure. Results: Out of 96 cases majority of cases were seen in the age group of 18-25 years (30.20%), followed by 26-33 years (23.95%). There was a slight male preponderance with 53.1% male and 46.9 % female. Majority (47.92%) of cases were brought to hospital during the 1st week of illness. Fever was common to all (100%) cases, followed by headache (62.5%), anorexia, and nausea (62.5%), abdominal pain (58.33%), diarrhoea (52.08%), and constipation (29.16%) and vomiting (8.33%). Less common symptoms were cough (14.58%), generalized weakness (8.33%), jaundice (4.16%), and bloody diarrhoea (2.08%). None of the patients had G.I bleeding or rash. Coated tongue was present in 83.33% patient. Hepatomegaly was present in 66.66% patients and more common than splenomegaly (41.66%).Only 41.66% patients were of toxic.......