DOI: 10.36347/sjmcr.2021.v09i01.004

Pages: 9-18

Wegener’s disease is a very rare condition in Africa. In 1931, a German student, Heinz Klinger, reported an unusual observation of peri-arteritis, this was characterized by pneumo-renal syndrome, severe airway involvement including rhinitis, nasal saddle, pan-sinusitis, middle ear, laryngo-tracheal and bronchial ulcerations and oneExophtamos. Autopsy examination revealed the presence of necrotizing and granulomatous vasculitis in the upper and lower airways, associed with increasing glomerulonephritis[1]. The objective of study is to show the existence of Wegener’s cases in our county, Observation: this is a 28-year-old patient followed by ENT for nasal-sinus polyposis, hospitalized for chronic cough with sputummuco-purulent sometimes streaked with blood with deterioration of the general condition; pathological examination of the biopsy nasal specimen concluded with the diagnosis of Wegener’s granulomatosis. Discussion: GW can be seen at all ages the average age at diagnosis is between 40 and 50years, with a slight male predominance in some series (table 23-11), which does not appear to be significant in the studies epidemiological[6]. Less than 15% of cases are pediatric. The presence of high titer ANCA with antiproteinase 3 specificity is a strong argument for the diagnosis of GW; on the other hand, the negativity of ANCAs should not make the diagnosis rejected, in particular in the face of a form of limited appearance. Histology remains a powerful and often essential diagnostic element, because, as often in systemic granulomatosis, the diagnosis can be discussed at the bordes of infections caused by intracellular bacteria and lymphoproliferative syndromes (in particular lymphoid granulomatosis of liebow) [80].