DOI: 10.36347/sjams.2021.v09i01.015

Pages: 77-81

Breast cancers are widely prevalent in females worldwide. Diagnosis and prognosis of carcinoma breast is effectively facilitated by the analysis of various hormone receptors and certain biomarkers. Ki-67 is an important proliferaive biomarker which is a nucleoprotein used for predicting these cancers. This study was carried out to review the distribution of histological subtypes and pattern of Ki-67expression in them. A part retrospective and part prospective study was done on a total of 59 cases of carcinoma breast. All stained slides were reviewed and the morphological diagnosis based on H & E staining was considered. For Ki-67 immounohistochemistry, representative sections from paraffin blocks were taken on poly- Llysine coated glass slides.Most common histogical subtype in our study was invasive ductal carcinoma followed by invasive papillary carcinoma.Ki67 score was maximum in metaplastic carcinoma followed by IDC with sqouamous metaplasia. Also ductal carcinomas had more ki67 proliferation activity than lobular ones. Further studies on large samples are required to correlate the Ki-67 to histological subtypes of breast cancer and to consider it as a significant prognostic factor of breast cancer.