DOI: 10.36347/sjams.2021.v09i01.020

Pages: 101-104

Background: The serum prostate specific antigen for the early detection and screening for prostate cancer are very common used among physicians as the best screening tool for prostate cancer. Objective: The objective is to determine the Significance Of Prostate Volume And Prostate Specific Antigen In The Diagnosis Of various Prostatic Diseases. Methodology: This prospective study was carried out at on 120 patients from July 2018- May 2019. All patients with lower urinary tract symptoms (LUTS), suggestive of prostate enlargement, were included. Patients with urethral strictures, calculi or with a previous history of surgeries and procedures on the prostate were excluded. All patients underwent digital rectal examination, serum PSA measurement and transrectal ultrasonography to measure prostate volume. Prostatic pathology was confirmed by biopsy in all patients after obtaining informed written consent. Results: The mean age was 70.05 ± 8.35 years. 52% of the patients had PSA values between 4- 10 ng/ ml. There was no statistical correlation between age and PSA. Digital rectal examination had a sensitivity of 65. 5% for detection of prostate cancer. Prostatic volume, as an independent variable, was not significant in predicting malignancy. Total PSA done in all cases was significant for the detection of cancer at levels >10 ng/ ml. Conclusion: Changes in prostate volume (PV) and serum prostate specific antigen (PSA) vary among different ages. Age is found to be significant but showed weak positive correlations with PV and PSA. Only PSA and PV demonstrated a significant and strong positive correlation. The study also demonstrated that serum PSA correlates with age, and this is due to increasing prostate volume with advancing age.