DOI: 10.36347/sajp.2021.v10i01.005

Pages: 24-27

Aminopyrine is used as an antipyretic and analgesic drug. It belongs to the pyrazolone derivatives having a most toxic and most dangerous analgesic effect and it is a non-narcotic drug. It had been widely used in the clinical treatment of rheumatism because of its good efficacy. It was inexpensive drug and due to this reason, it was widely used in many countries. It causes agranulocytosis, aplastic anemia and blood dyscrasias in many patients. In this review, we are providing an overview of fatal side effects of aminopyrine drug such as neutropenia, acute renal failure, bone marrow depression and damage to stomach which are reported and make it banned in many countries. Because of its serious adverse effects, it has been withdrawn from most of the countries like France, Thailand and India. Aminopyrine is rarely used in the Europe like countries at present. In 1986, it was forbidden in Japan. The Committee on the Safety of Drugs of the Japanese Pharmaceutical Affairs Bureau has ordered for its withdrawal. Before that it was extensively used as analgesics, until its side effects were not reported. Even though it is in use at present time in some developing countries.