DOI: 10.36347/sasjm.2021.v07i01.006

Pages: 26-33

Background and Aim: Non-small cell lung cancer (NSCLC) is one of the most common clinical malignant tumors. According to the World Health Organization (WHO), NSCLC has become the most common malignant tumor with the highest morbidity and mortality. This paper aims to investigate the mechanism of LncRNAG058036 in NSCLC. Methods: LncRNAG058036 was screened out by bioinformatics analysis, and the expression of G058036 in NSCLC tissues and adjacent non-cancer tissues was compared by quantitative real-time polymerase chain reaction. Survival analysis of Patients with G058036 in NSCLC.G058036shRNA was used to transfection NSCLC A549 and H838, and proliferation, invasion and apoptosis were observed by comparing the experimental group with the control group. Results: LncRNAG058036 was significantly increased in NSCLC tissues, and G058036 knockout could significantly inhibit the proliferation, invasion and apoptosis of A549 and H838 cells. Conclusion: LncRNAG058036 is up-regulated in NSCLC and may be a potential target for diagnosis, treatment and prognosis of NSCLC.