DOI: 10.36347/sjmcr.2021.v09i03.007

Pages: 221-226

Synovial sarcomas are malignant, high-grade, soft-tissue neoplasms that are estimated to represent between 5% and 10% of all soft-tissue sarcomas. In fact, in adults, synovial sarcoma is the fourth most common type of sarcoma after malignant fibrous histiocytoma, liposarcoma and rhabdomyosarcoma. It predominantly affect the extremities but can occur in any part of the body, including the head and neck. This tumor is most prevalent in adolescents and adults between 15 and 40 years of age. Concerning gender incidence, the male: female ratio is 1.2:1, with males being more frequently affected. Synovial sarcomas not only are locally aggressive but also have a higher metastatic potential than most other soft-tissue sarcomas. Hence, the overall prognosis for synovial sarcoma patients is poor. We reported a case of synovial sarcoma with neuronal differentiation located on the dorsal aspect of the right foot of an 38 years old male. This case illustrates the neuronal differentiation of the tumor which could have been misdiagnosed as neuronal tumor in FNAC and the challenges to differentiate it from other biphasic tumors. Thorough HPE examination and immunohistochemistry are mandatory for early diagnosis and to avoid misdiagnosis.