DOI: 10.36347/sjams.2021.v09i03.019

Pages: 390-392

Background: Long term toxicities of imatinib are important as patients need to take it for a long duration probably for lifetime. Effect of imatinib on serum calcium and phosphate has been shown in few studied. We planned this study to evaluate the effect of imatinib on bone health. Material and Methods: In this study bone health of 104 patients of CML and 104 normal healthy individuals was assessed and compared by Serum Calcium, Serum Magnesium, Serum Phosphorus, Serum Vitamin D, Serum Alkaline phosphatase, and DEXA scan. Results: Mean serum calcium level was 9.25 mg/dl in CML patients and 9.53 mg/dl in normal healthy individuals (p value < .01). Level of serum phosphorus was 2.15 mg/dl in CML patients versus 3.41mg/dl in normal controls (p value < .001). Mean serum vitamin D level of CML patients was 27.96 ng/ml versus 23.85 ng/ml (p value < .01). Mean BMD of CML patients was -0.83 versus -0.99 in normal individuals. (p value > .05). Conclusion: Long term use of imatinib in CML patients affects the bone health significantly and may impact the quality of life.