DOI: 10.36347/sjams.2021.v09i03.023

Pages: 404-409

Background: The study was designed to explore lipid profile and electrocardiographic changes associated with thyroid dysfunctions. Materials and Methods: A total of 50 Newly diagnosed hypothyroid patients (who were not on any treatment or were on treatment for less than 3 months) were investigated with lipid profiles and electrocardiogram (ECG). Purposive sampling was used to recruit the desired sample from the population of patients that met inclusion-exclusion criterion for the present observational study. The comparisons of lipid profile parameters and ECG changes was carried out statistically with respect to severity of hypothyroidism. Results: The study population comprised of males and females between the age group of 27-74 years and the mean age group in this study was 49.46 years. There was a female preponderance consisting of 82% of total study population. The commonest finding in our study was presence of Low voltage complex; accounting for 66% of population, followed by Sinus Bradycardia in 26% population. Evidence of dyslipidemia was noticed in 60% of population. The average total cholesterol with (225.33±115.05 mg/dl), mean serum LDL (153±31.75 mg/dl), the mean Triglyceride levels and ratio of LDL and HDL in patients with severe TSH was significantly elevated. Conclusion: Hypothyroidism has significant impact on both cardiovascular system as well as Lipid profile, being more common in female patients. The commonest electrocardiographic change noted in our study was presence of Low voltage complex followed by sinus bradycardia. Qtc interval was also prolonged in significant no. of patients. Mean cholesterol, serum LDL and serum TG levels were significantly elevated but the serum HDL was significantly reduced among severe grades of TSH as compared to mild and moderate grades of TSH and were statistically significant.