DOI: 10.36347/sjams.2020.v08i12.043

Pages: 2910-2915

Solid Pseudopapillary Epithelial Neoplasm (SPEN) are rare pancreatic tumours, which have generated curiosity of surgeons due to their variable biologic nature. We report three cases of SPEN in young females presenting with hematemesis, nausea, anorexia, abdominal pain and weight loss. Based on computed tomography each of these cases were found to have the neoplasm in pancreas with portal vein (PV) involvement. SPEN is a benign tumour with only 5% displaying malignant features [1]. All three cases were managed by Whipple's pancreaticoduodenectomy with PV resection and reconstruction. Histology and immunohistochemistry confirmed the diagnosis of SPEN in all cases. All cases were followed up and after one year all revealed a patent PV graft with normal flow pattern and no recurrence of disease. Since SPEN has low malignant potential with a favourable prognosis, aggressive management should be pursued. PV invasion by the lesion is neither a contraindication for surgery, nor does it indicate poor prognosis. SPEN with vascular invasion can be managed safely with vascular resection and reconstruction and has a good prognosis.