DOI: 10.36347/sasjm.2021.v07i03.006

Pages: 90-95

Lyell syndrome and Stevens-Johnson syndrome (SJS) are two rare but potentially life-threatening mucocutaneous disease. The aime of our study is to describe their cutaneous, mucosal and ophthalmological damage in children, and to study the correlation between the severity of cutaneous and ocular damage based on the prognostic scores of the disease. It’s a retrospective study involving 16 files, collected over a period of 4 years, and retained before the existence of an associated eye injury. The average age of children was 7 years with a 5/3 sex ratio. 9 of our patients were classified according to the SCORTEN score in score II, 4 in score IV and 3 in score V whose evolution was unfortunately death. Ocular damage has been reported in all our patients, it interested at the acute phase two sites: conjunctiva and cornea, and at late phase eyelid architecture abnormalities. All of our patients had dry eyes syndrome and one case of corneal blindness was reported. According to Foster’s classification, 7 patients were classified as Stage I, 5 as Stage II and 4 as Stage III. Stage 1 included 86% of SJS, Stage II 22% of SJS and 42.85% of Lyell, while Stage 3 included only Lyell cases, which make the correlation between the severity of ocular and cutaneous involvement and the prognosis of the disease. Lyell’s syndrome and Stevens-Johnson syndrome are most often drug-induced dermatological emergencies. They can engage the vital prognosis in 1/3 of cases as well as the functional and aesthetic prognosis by their cutaneomucosal and ocular damage. There is a correlation between the severity of ocular and cutaneous involvement as well as the overall severity of the disease. This is quite evident while seeing the association of severe stages according to the Foster classification to the most severe stages of SCORTEN score.