DOI: 10.36347/sjmcr.2021.v09i03.030

Pages: 303-306

Gayet-Wernicke encephalopathy is an acute neurological complication due to thiamine deficiency. The diagnosis can be difficult to make since the clinical forms can be poor or atypical. Although it is often associated with chronic alcoholism, it can also occur in all the conditions that lead to thiamine deficiency: undernutrition, chronic vomiting, prolonged fasting, and exclusive artificial feeding. It is a rare complication, reversible if is promptly treated. We report two cases of Gayet-Wernicke encephalopathy, the first occurred in a pregnant patient suffering from uncontrollable vomiting and the second patient treated with methotrexate for rheumatoid arthritis with a chronic uncontrollable vomiting due to digestive intolerance to Methotrexate (only cause found).