DOI: 10.36347/sjams.2021.v09i04.012

Pages: 549-553

Introduction: Acne vulgaris is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles. Typical features of that condition included blackheads or whiteheads, pimples, oily skin and possible scarring. The aim of the study was to assess the efficacy and safety of dapsone gel in the Treatment of Acne Vulgaris. Method: A clinical trial was carried out at Upazilla Health Complex, Fulpur, Mymensingh during the period from January 2018 to December 2018. Total fifty (50) patients of clinically diagnosed mild to moderate acne vulgaris were enrolled and thirty (30) of Group I patients were treated by dapsone gel and another thirty of Group II patients were treated by Clindamycin cream over 28 days in patients with moderate acne vulgaris. Result: At baseline mean number of comedones in Group I and Group II were 13.11±3.67 and 12.12±3.61, respectively (p=0.415) and at final follow-up 4.10±4.11 and 4.50±3.10 in each group (p>0.05). At baseline mean number of papules in Group I and Group II were 18.11±9.48 and 19.01±13.44, respectively (p=0.725) and at final follow-up 8.02±7.69 and 8.03±9.68 (p>0.05). At baseline mean number of pustules in Group I and Group II were 0.49±1.43 and 0.50±1.31, respectively (p=0.897) and at final follow-up 0.08±0.36 and 0.00 (p>0.05). At baseline mean of total acne score was 29.96±14.23 and 30.90±17.17 in Group I and B and at final follow-up, it was 11.87±12.04 and 11.20±13.85, respectively in Group I and B (p>0.05). Percent reduction of acne severity from baseline to final follow-up was 69.20±23.41 in Group I and 74.77±23.30 in Group II (p=0.393). At final follow-up, 56.7% of Group I and 63.3% of Group II achieved excellent response and 13.3% of Group I and 16.7% of Group II achieved a good response. Conclusion: The study can conclude that dapsone gel was found to be more effective than Clindamycin cream in the treatment of acne vulgaris. This study demonstrated lower systemic exposure with dapsone ......