DOI: 10.36347/sasjm.2021.v07i04.004

Pages: 139-144

Ulcerative colitis (UC) is the chronic non-specific intestinal inflammatory disease. The purpose of this study is to establish a UC mouse model and explore the improvement effect of Portulaca oleracea L. polysaccharide (POL-P) on the UC experimental model. Dextran Sulphate Sodium Salt (DSS) concentration screening for establishing UC mouse model was used 2% DSS, 3% DSS and 4% DSS, respectively. Disease activity index (DAI) was recorded daily. Mice were sacrificed at the end of the experiment. The length of the colon and morphological structure of colonic tissue were analyzed. To further evaluate the safety of POL-P, the morphology analysis of liver and kidney tissue sections was performed. The results showed that 4% DSS was the optimal modeling concentration. POL-P had obvious prevention and treatment effects on UC mice. And POL-P has no toxic side effects on the liver and kidney tissues of mouse. The experimental results provide a theoretical basis for developing POL-P into a new drug with high efficiency and low toxicity for the prevention and treatment of UC.