DOI: 10.36347/sjams.2021.v09i04.026

Pages: 621-628

Background: Changes in serum ferritin levels are associated with glucose intolerance. Objectives: The objective of the study was to see serum ferritin and HbA1c level in newly detected prediabetes participants. Materials and Methods: This cross-sectional study included 200 participants categorized by American Diabetes Association diagnostic criteria, 2016. Prediabetes was further categorized as impaired fasting glucose, impaired glucose tolerance, and IFG+IGT. Serum ferritin level was measured by using N Latex ferritin while HbA1c level by high-performance liquid chromatography. Results: Prediabetes participants had significantly higher age (35.4±1.03 vs. 30.3±0.9 years, mean± SEM; p<0.001); waist circumference (94.1±11.5 vs. 89.5±11.1 cm, mean± SD; p=0.004); systolic & diastolic blood pressure (122±11 vs. 118±11, p=0.013 & 79±6 vs. 75±8 mm of Hg, mean± SD; p<0.001, respectively); with more family history of diabetes and hypertension than normal glucose tolerance (61% vs. 45%, p<0.001, 14% vs. 5%, p<0.001, respectively). Mean serum ferritin level was found to increase in the subgroups with the prediabetes (NGT: 76.8±6.6; IFG: 105.3±16.0; IGT: 145.1±13.5 and IFG+IGT: 130.1±12.4 ng/ml; respectively, p<0.001). HbA1c level showed an increasing trend with subclasses of increasing intensification of dysglycemia: 5.0±0.1; IFG: 5.5±0.1; IGT:5.7±0.1; IFG+IGT: 5.8±0.1 percentage; p<0.001). Within each subgroup of prediabetes serum ferritin level was found comparably higher in the participants having HbA1c>6% [HbA1c<5.7 vs. ≥5.7-6 vs.>6 -for IFG+IGT (116.2±12.4 vs. 117.6±23.6 vs. 150.0±25.1 ng/ml, p=0.419)]. Males had higher serum ferritin level than females- for NGT (139.4±17.3 vs. 53.7±3.9 ng/ml, p<0.0011), IFG (138.0 vs. 94.3±16.6 ng/ml, p=0.319), IGT (208.6±19 vs. 129.6±15 ng/ml, p=0.019) and IFG+IGT (166.3± 27.4 vs. 108.3± 9.2 ng/ml, p=0.021). Serum ferritin level was higher in participants with advancing age also higher in the hypertensive group than that in ........