DOI: 10.36347/sasjs

Pages: 118-121

Syndrome of inappropriate antidiuretic hormone secretion is a clinical syndrome which enhance the secretion or action of ADH (antidiuretic hormone),which causes the body to retain water and certain levels of electrolytes in the blood to fall (such as sodium) .It is the most common cause of hyponatremia seen in hospitalized patients. It has various etiologies like malignancy, pulmonary diseases, CNS diseases and some medications. Symptoms of SIADH depend on the degree of hyponatremia and the rate at which it develops. Serum sodium below 120mmol/L can cause life-threatening symptoms, while gradual decline causes nonspecific symptoms. Vasopressin-receptor antagonists (vaptans) would provide a more effective method to treat hyponatraemia secondary to SIADH. The review focuses on syndrome of inappropriate antidiuretic hormone secretion as a cause of Hyponatremia and management of it which may help in the prevention of Hyponatremia.