DOI: 10.36347/sjmcr.2021.v09i05.041

Pages: 614-616

Subacute cerebellar degeneration is one of the classic paraneoplastic neurological syndromes. It may be isolated or is only part of a larger nervous system involvement. We report the observation of a 45-year-old patient with no pathological history who presents an isolated cerebellar syndrome that has progressed for 3 months and has gradually worsened. Cerebral MRI found, in addition to cerebellar atrophy, thickening of the lining of the cavum which led to an ENT examination with biopsy of the cavum allowing confirmation of the undifferentiated corcinoma of the UCNT type. The patient was referred to the oncology department for management. Depending on the clinical and immunological criteria, different sub types of paraneoplastic cerebellar ataxias can be defined. These syndromes correspond to an autoimmune process originally directed against the tumor. They often have a devastating and irreversible course because they are accompanied very quickly by neuronal degeneration. Two therapeutic axes have been proposed: immunosuppressive therapy and tumor treatment. The prognosis of these syndromes can only be improved with the fastest possible diagnosis and treatment of cancer.