DOI: 10.36347/sajb.2021.v09i05.004

Pages: 139-144

Silica nanoparticles (SiNPs) are encapsulated in an ecological platform has been planned to supply many benefits, and blood vessels used as laser-tissue-soldering within the brain, and during the course of the degradation, SiNPs given to the discharged into an encircling of the brain tissue. The goal of this modern research was to examine likely to the silicon dioxide nanoparticles are categorized in the microglial cells and uptake the cellular mechanism(s), and additionally these impacts on autophagy and inflammatory cytokines, and also it's been found in depth applications in medical specialty and biotechnological fields, for example, bio imaging, medical diagnostics, gene therapy, drug delivery, photodynamic therapy biomolecule detection and bio-imaging. It has also been added to the raising of the industrial mechanism to the exposure of silicon dioxide nanoparticles, throughout the manufacturing, transportation, storage, and consumers that are obviously increased used by human exposure and environmental burden. The purpose of this work was to examine the neurotoxicity of two different dosages (40 and 80 mg/kg body weight) of silica nanoparticles (SiNPs) in male albino rats for 14 days by intraperitoneal exposure. The neurobehavioral and neurochemical changes were analyzed. Spontaneous motor activity, catalepsy, gait and muscle incoordination were assessed. There after the brain was removed for the examination of lipid peroxide level and antioxidant enzymes (SOD and CAT). Our results indicated the SNPs could passed from the blood-brain-barrier into the brain, and essentially it increases the concentration of lipid peroxide levels and reduce the activity of SOD and CAT and also its reduce the behavioral activity were seen. The maximum changes were observed in rats, who received 80 mg/kg body weight doses. It can be concluded that neuronal toxicity of silica nanoparticles could be related to the amount of the particles and the oxidative stress could be ............