DOI: 10.36347/sasjm.2021.v07i05.010

Pages: 204-207

Introduction: Breast cancer is the most commonly happening female cancer and the leading cause of cancer deaths worldwide. Breast cancer is a heterogeneous disease and it encompasses a variety of entities with distinct morphological appearances and clinical behaviors. Triple-negative breast cancer (TNBC) represents 12.5– 15% of all breast cancers. Its molecular dissimilarity also brings a significantly different clinical course. It has been observed that basal-like breast cancers exhibit a gene expression profile very similar to that of myoepithelial cells. Aim of the study: To identify the basal like TNBC cases and correlate them with histomorphological grade. Material & Methods: This cross sectional study was conducted in the department of BSMMU from January 2016 to December 2017. A total of 41 cases previously diagnosed as TNBC by histological and immunohistochemical examinations were selected for the study. During collecting specimen, all relevant information were recorded systemically in a prescribed proforma. Histopathogical type of tumor was done according to WHO classification of breast tumor, 2012 and grading was done followings Nottingham modification of the Bloom -Richardson Grading System, and recorded. Immunohistochemistry of ER, PR and HER-2/neu expression of all cases were performed using Dako Autostainer Plus at the immunohistochemistry laboratory, of department of Pathology, BSMMU. Statistical analyses of the results were obtained by window based computer software devised with Statistical Packages for Social Sciences (SPSS-20). Prior to the commencement of this study the thesis protocol was submitted to the Institutional Review Board (IRB) of BSMMU, Dhaka for approval and was approved. Results: A total number of 41 cases were selected for the study out of these 41 cases; most of the cases belong to a range of 31 to 40 years. Minimum age was 26 years, maximum age was 70 years. The mean age was 42. There is no association between age and CK 5/6 ......