DOI: 10.36347/sjams.2021.v09i05.024

Pages: 746-750

CT perfusion, the measurement of blood flow characteristics through dynamic CT acquisitions following intravenous administration of contrast agents, can easily be integrated into routine CT imaging protocols within the same imaging session. Clinical applications of CT perfusion imaging for earlier detection of hepatocellular carcinoma are being assessed in this study. The study was conducted in the department of Radiodiagnosis MOSC medical college, Kolencherry from January 2018 to March 2020. Total 56 patients were included in the study. Imaging done on 64 slice CT. For Analysis, data were processed at a workstation. Functional maps of HBF (hepatic blood flow), HBV (hepatic blood volume), MTT (mean transit time), TTP (time to peak), HPI (hepatic perfusion index) and PSAP (permeability surface area product) were generated. Statistical analysis has been carried out in the present study. Wilcoxon signed rank test was used to compare the perfusion parameters of HCC (hepatocellular carcinoma) and background liver parenchyma. All data were expressed as mean ± SD, and statistical analysis was performed with RStudio. Wilcoxon-signed ranks test (nonparametric test) of variance was used to compare the differences in CT perfusion parameters. P < 0.05 was considered statistically significant. Wilcoxon signed rank test was used to compare the perfusion parameters between the background liver and HCC. In our study there was significant increase in HBF, HBV, PSAP, and HPI whereas TTP and MTT was significantly reduced in HCC compared to background liver.Our results were comparable to the reference studies.