DOI: 10.36347/sajb.2021.v09i06.004

Pages: 166-170

Introduction: Rapidly progressive glomerulonephritis (RPGN) is a type of GN disease of the kidney. It is clinically characterized by a rapid decrease in the glomerular filtration rate (GFR) of at least 50% over a short period, from a few days to 3 months. The main pathologic finding is extensive glomerular crescent formation. The present study was conducted to recognize the morphological pattern in RPGN, underlying causes, and the outcome of RPGN in children. Aim of the study: To assess the histopathology of Rapidly Progressive Glomerulonephritis (RPGN), as RPGN can cause rapid irreversible damage to renal glomeruli in the form of crescents. Methods: This study was done on 34 RPGN children at the department of pediatric Nephrology in Dhaka Shishu (Children) Hospital over the period of June 2017 to December 2019. Result: The etiology of RPGN in this study showed, HSP nephritis was the commonest (23.5%) followed by IgA nephropathy (21.9%) and postinfectious glomerulonephritis (17.64%). Hematuria, proteinuria, and edema were present in almost all cases. The proportion of glomeruli displaying cellular crescent was 21%, fibrous crescent 7.1%, and fibrocellular crescent was 35% respectively. In terms of outcome, 61.7% of patients exhibited total recovery of renal function, 14.7% of patients were lost during follow-up, 5.8% were dialysis dependant, 5.8% patients developed chronic kidney disease and 11.7% died during hospitalization. Conclusion: RPGN is one of the important causes of unexplained acute kidney injury (AKI). Rapid and irreversible loss of renal function and remarkable mortality consider the need for awareness and development of a specific registry for Pediatric RPGN in hospitals.