DOI: 10.36347/sajb.2021.v09i07.002

Pages: 175-181

Astaxanthin is a carotenoid pigment commonly found in a marine organism such as algae, salmon, and also the main pigment in shrimp shell waste. Astaxanthin possesses antioxidant activity that able to suppress oxidative stress caused by hyperglycemia on β – pancreas cell. Shrimp shell waste can be utilized to produce astaxanthin to minimalize waste production. This study aims to find out the ability of shrimp shell crude extract activity in decreasing blood glucose level in rats induced diabetes. Shrimp shell was extracted using the maceration method with ethanol 70% as solvent. Thin-layer chromatography was used as semi – qualitative analysis method continued by spectrophotometry as a quantification analysis. Bioassay test was conducted using Rattus norvegicus rat conditioned with diabetes induced by Streptozotocin. Shrimp shell crude extract was given per oral every day for one month. Measurement of blood glucose level conducted using glucometer every once a week. The resulting yield extract is 0,039%. Thin-layer chromatography show 3 spot with canthaxanthin, astaxanthin monoester and β – carotene as a compound assumption. A blood glucose reduction test with a dose of 37,5 mg/kg BW show the best result. Average blood glucose level could be decreased from 429,8 mg/dL to 140,6 mg/dL.