DOI: 10.36347/sjams.2021.v09i07.007

Pages: 1158-1165

Respiratory distress syndrome, resulting from a deficiency of surfactant, is the most frequent clinical respiratory disorder in preterm infants. It is the most critical cause of morbidity and mortality in preterm infants. The present study INSURE was done in a total of 100 Preterm neonates who came with respiratory distress syndrome with <35 wks and <1.5kg to NICU, Department of Pediatrics, King George Hospital, Andhra Medical College, Visakhapatnam from January 2018 to July 2019 to know the usefulness of INSURE in a resource-poor setting where the only surfactant is given with NCPAP, where a poorer patient can afford and can decrease the morbidity and mortality of MV. This study concludes that, among spontaneously breathing, premature infants treated with INSURE, decreased the need for subsequent MV by 22%. The higher birth weight, the use of antenatal steroids, the lower RDS score at the time of the procedure, and the early use of surfactant as the good predictors in the INSURE success group. There is a significant decrease in the need for MV in the surfactant group compared to the control group. The reduction in the need for MV decreased the risk of air leak syndrome and is advantageous in medical settings where resources are limited, like in our country.