DOI: 10.36347/sjmcr.2021.v09i07.006

Pages: 711-714

Creutzfeldt-Jakob disease or subacute spongiform encephalopathy is a rare prion encephalopathy with a long incubation period and fatal outcome without remission. In this summary, we report a case of sporadic Creutzfeldt-Jakob disease consolidates by positive income CSF analysis of the 14.3.3 protein. This patient study report presents a 54 years old Moroccan male patient with no underlying disease. Whose history of the disease goes back to 04 months, by the admission at the department of psychiatry for the quickly progressive installation of a depressive syndrome, with behavioral disorders made up of anxiety and aggression towards, associated with a decline in visual acuity that the patient reported as very annoying and disabling, while the ophthalmologic examination without abnormalities, and the patient was able to walk alone and avoids obstacles while walking. With a strictly normal brain MRI, treatment by antidepressants and neuroleptics has been prescribed. The evolution was marked 3 months later by the appearance of significant memory disorders associated with hallucinations, impaired walking, and myoclonus in the upper limbs which are exerted by sounds in the arms and legs. A new brain MRI performed showed bilateral frontal and occipital cortical high signal, a visual evoked potential demonstrated a decrease in the activity of the visual pathways with alteration of the central macular vision, the electroencephalogram (EEG) revealed a slowing of the background activity with periodic activity and rapid rhythmicity, the study of Cerebrospinal fluid (CSF) was without abnormalities regarding CSF value of proteins and glucose but the dosage of the protein 14.3.3 came back positive. Following these clinical, biological, radiological, and electrophysiological elements, the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) was retained.