DOI: 10.36347/sjams.2020.v08i12.044

Pages: 2916-2921

Background: The prevalence of bacterial infections is a major cause of morbidity and mortality in patients. Inappropriate and irrational use of antibiotics has led to increasing resistance in commonly isolated gram positive and gram-negative organisms. Antimicrobial resistance is a matter of concern as it compromises the management of infectious diseases and increases the cost of health care as well. Aims and Objectives: The Aims of this study includes Isolation and identification of pathogens from various clinical samples and their antibiotic susceptibilities patterns in a tertiary care centre, Rajasthan. Materials and Methods: This retrospective study was conducted in Department of Microbiology. The records of bacteriology section were compiled for a period of 12 months from October 2016 to September 2017. The results were consolidated for types of clinical samples, organisms isolated and their susceptibility patterns. Results: A Total of 352 samples were received in Department of Microbiology over a period of one year from October 2016 to September 2017.Out of 352 samples 129 (36.64%) were positive on culture. In this study E. coli, 27(20.9%) was the predominant isolate followed by Pseudomonas spp, 23(17.8%) and Staphylococcus aureus, 20(15.5 %). The susceptibility pattern in E. coli to Ceftazidime, Gentamicin and Meropenem were 81.4%, 59.2% and 96.2% respectively and in Pseudomonas to Piperacillin/Tazobactam and Meropenem both were 87.0%. Among S. aureus, 50.0% strains were Methicillin resistant. Conclusions: Gram negative bacteria still remain the predominant causes in most of the clinical infections in health care settings. E coli were the most common organism in most of the cases. Antimicrobial resistance is a major challenge and antibiotics need to be tested and prescribed according to standard guidelines. Local anti-biograms should be available periodically to help clinicians guide on antibiotic prescribing.