DOI: 10.36347/sjams.2021.v09i07.021

Pages: 1241-1247

Introduction: Thalassemia and Hemoglobinopathies are the two most common monogenic disorders involving synthesis of hemoglobin molecule. In India the prevalence of β thalassemia carriers is 3-4%. Several ethnic groups have a much higher prevalence of 4-17%. HbE is the most common hemoglobin variant found in Asian population, In India it is prevalent in NE India and Eastern region where the frequencies of HbE carriers range from 3 to over 50%. Coinheritance of HemoglobinE and βthal variants is not uncommon in regions where both are prevalent. The clinical manifestations in thalassemia is due to resultant anemia due to ineffective erythropoiesis, and is mainly treated with blood transfusion which results in deposition of iron and hemosiderin in the renal tubules , heart, liver, spleen and endocrine organs. Aim: 1. To evaluate the kidney function and liver function of βthalassemia major and heterozygous βthal-HbE. 2. Correlate the hematological and biochemical status of βthal major and βthal-HbE patients with iron overload. Materials and methods: This study designed as a case-control study, was conducted in Biochemistry Section of Central Clinical Laboratory, Gauhati Medical College & Hospital during the time period from October 2019 to July 2020. Patients suffering from βthalassemia major, HbE-βthalassemia were selected as cases and age matched controls were selected from healthy relatives of patients, and patients attending ENT, Ortho and Surgery OPD. For Liver function assessment AST, ALT, ALP, Tbil, TP was done and for Kidney function assessment urea, creatinine, uric acid, calcium was done. To assess the iron overload Iron, TIBC, Ferritin was done. Results & Observations: Hb levels in the case group were decreased to 60% of levels reported in the control group (7.08±1.66 vs 11.72±1.17). Iron level in the case group, all of whom were receiving regular blood transfusions, was found to be significantly high with a p-value of <0.0001. The level of Ferritin, .........