DOI: 10.36347/sjmcr.2021.v09i08.013

Pages: 808-810

In this case study the aim is to highlight the role of Alpha-2 agonists to reduce vasopressor requirements in septic shock. In fact the case presented to us is an 11-month-old child admitted for burns on the whole body. The usual treatment does not seem to be very effective, so the hospital's medical team decided to inject him with a α 2-adrenoceptor agonists: Remarkable results have emerged at the end of this treatment. It has been proven that Clonidine reduces sympathetic nerve activity to the heart and vasculature by a direct central action, which is its main mechanism of action as an antihypertensive drug. With reductions in sympathetic nerve activity to other organs, this is likely associated with a decrease in plasma catecholamines concentrations. This substance has a special mechanism which has proven a succes in septic shock.