DOI: 10.36347/sajp.2012.v01i01.006

Pages: 30-33

Abstract – The present study aimed evaluate the protective effect of citrullus lanatus seed oil against CCl4 induced hepatic damage in rat. The hepatoprotective was on carbon tetrachloride induced hepatotoxicity in rats by estimated serum hepatic enzyme levels and hisopathological study of liver tissues. Citrullus lanatus seed oil ; CLSO (125mg) and CLSO(250mg) were administered orally for 10 days in rats and compared with standard silymarin (100 mg/kg) orally. The results showed significant decrease in serum ALT, AST and ALP levels treated groups which were increased due to CCl4 induced liver damage are comparable with standard drug. Histopathological study of liver tissue ravels the hepatoprotective activity of Citrullus lanatus seed oil.