DOI: 10.36347/sjams.2021.v09i09.028

Pages: 1458-1465

Background: Weaning is the term frequently used to describe the gradual reduction of ventilatory support from patient who’s pulmonary and other conditions are improving. Delayed weaning from ventilatory support expose patients to unnecessary complications. Patients should therefore be weaned from mechanical ventilation as quickly as possible. Objective: The purpose of the study was to compare the serum level of BNP between weaning successful and weaning failed patients. Methodology: This study was a prospective cohort study. This study was conducted in the Department of Anesthesia, Analgesia and Intensive Care Medicine at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh over a period of 2 years. Study population was selected for weaning from mechanical ventilation support for the first time in the age group of more than 18 years with both sexes. Patients with pre-existing diseases that elevate the plasma BNP level were excluded from the study. Weaning criteria was selected by ICU consultant following the standard ICU protocol for every patients enrolled in this study. Patients were subdivided into weaning success and weaning failure groups according to the outcome of weaning process. Plasma BNP level of all patients was measured before and after 2 hours of spontaneous breathing trial. Each blood sample (3ml) was collected by ICU lab technician into a vacutainer with EDTA for anticoagulation. Blood samples were sent to the biochemistry lab and analysis was done by chemiluminescent microparticle immunoassay (CMIA). Serial arterial blood gases done within ICU lab before and after 2hours of SBT and 12hourly up to 48 hours. Patients who were extubated would be followed up for 48 hours after SBT. Result: A total number of 30 patients were recruited for this study. One-third (33.3%) of the patients failed on SBT. The mean age of weaning success and failure groups were 54.90±9.787 years and 57.60±10.091 years respectively. The mean percent changes ............