DOI: 10.36347/sjams.2021.v09i10.002

Pages: 1493-1496

Background: Chronic myeloid leukemia (CML) is a clonal BCR–ABL1-positive myelo-proliferative disorder resulting from an acquired genetic mutation, characterized by the presence of the Philadelphia chromosome. CML is associated with significantly high granulocyte numbers in the bone marrow and peripheral blood. Methods and Material: This retrospective study conducted at the Hematology Laboratory of the Military hospital Avicenna in Marrakech aimed to assess the epidemiological, clinical and cytological profile of the CML. We have evaluated the demographic, clinical, and hematological data of 42 patients from January 2013 to May 2019. Results: A total of 42 cases of CML were included. The average age was 42 years. The male gender was predominant with a sex-ratio (M/F) at 3. The most frequent reason for consultation was splenomegaly (90%) either isolated or associated with a deterioration of the general condition and / or a hemorrhagic syndrome and / or thrombosis. All patients were diagnosed in the chronic phase. The complete blood count (CBC) had showed hyperleukocytosis exceeding 20G / l in all our patients. A normochromic normocytic anemia was showed in 96% of cases. Thrombocytosis in 14% of cases. All patients had smear myelemia blood. All patients underwent a myelogram, which revealed hyperplasia of the granular line with the presence of numerous dystrophic megakaryocytes. A cytogenetic study was performed in 20 patients (47,6% of cases) and which revealed the Philadelphia chromosome, thus confirming the diagnosis of CML in these patients. Conclusion: A patient with an increased WBC count, abdominal pain, left side distension, and hepato-splenomegaly should clearly be evaluated for CML. Exploration of CML in diverse populations can provide a deeper understanding of its molecular characteristics and thereby help in finding better treatment opportunities.