DOI: 10.36347/sjams.2021.v09i10.015

Pages: 1565-1568

Background: Diabetes mellitus is one of the most widespread endocrine disorders and its complications are increasing all over the world. Hyperglycemia causes excess free radicals generation leading to oxidative stress which is responsible for micro vascular and macro vascular complications. Serum malondialdehyde (MDA) level may reflect oxidative stress in type 2 DM. Vitamin C has been suggested to be an important antioxidant for scavenging oxygen-derived free radicals. Objective: To observe the effects of oral supplementation of vitamin C on biomarker level of oxidative stress in patients with type 2 diabetes mellitus. Method: From July 2015 to June 2016, a prospective interventional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka. A total of 33 diagnosed type 2 diabetic patients of both sexes with age ranging from 40 to 55 years were chosen. The study group consisted of 17 type 2 diabetic patients who received vitamin C (1000 mg/day) supplements for 6 weeks. Another 16 age-matched type 2 diabetic patients were used as a control group for comparison, with no vitamin C supplementation. All subjects in both groups were studied twice, once at the beginning of the study (baseline) and once after 6 weeks of study. Result: At the beginning of the study, the mean MDA level was almost identical, and the difference between the control and study groups was not statistically significant (baseline). The mean serum MDA level in diabetic patients was significantly (p<0.001) reduced after six weeks of vitamin C supplementation compared to their baseline value. Again, after 6 weeks, serum MDA level was significantly (p=0.002) lower in vitamin C supplemented patients compared to control group who were not supplemented with vitamin C. Conclusion: Supplementation of vitamin C is found effective in reducing the biomarker level of oxidative stress.