DOI: 10.36347/sjams.2021.v09i10.019

Pages: 1584-1590

Background: Ovarian cancer is a disease of significant morbidity and mortality. It is the most common cancer among women worldwide. Early and accurate detection and grading of ovarian serous carcinoma is of utmost significance for prolongation of patient survival. Panels of immunomarkers have been tested to overcome limitation of histopathology. Immunomarker p53 is commonly used among them. This study was undertaken to evaluate the significance of p53 immunomarker in ovarian serous carcinoma. Objective: Objective of this study to see p53 expression and its association with different histopathological grading of ovarian serous carcinoma. Method: This cross-sectional study was conducted in the Department of Pathology, Rajshahi Medical College, over a period of two years from July 2017 to June 2019. A total of 32 clinically suspected cases of ovarian carcinoma admitted in the RMCH and later on histologically confirmed as ovarian serous carcinoma were included in the study. Histories of the patient were obtained from the hospital records. Tissue biopsy from the site of lesion or operated specimen of tissue was fixed with 10% formalin and was processed stained with haematoxyline and eosin stain and was examined. Result: Immunohistochemistry was done for p53 from significant paraffin embedded block. Of the 32 cases 20 were histologically confirmed as high grade and the rest 12 were low grade ovarian serous carcinoma. In this present study, age distribution showed that, about 60% of the patients were within 2nd to 5thdecades.The mean age of the patients was 41.34 years. The sensitivity of p53 was found high (80.2%) in case of serous ovarian carcinoma and its different grade. Conclusion: The study concluded that p53 is a highly sensitive immunomarker for detecting the grade of ovarian carcinoma specially serous ovarian carcinoma.