DOI: 10.36347/sjams.2021.v09i11.005

Pages: 1674-1679

Silica nanoparticles (SiNPs) are found to be toxic during excessive exposure for both human and animals (Fan et al., (2006). The main routes of exposure are air, drinking water and other environmental factors (Leung et al., 2012). It is reported that SiNPs decreased the sperm number and sperm motility rate, sperm malformation and apoptosis in the testicle spermatogenic cells in rats (Ying et al., 2014). Aim of the present study is to evaluate deterioration induced by SiNPs in male reproductive hormones. In the present study, 40 and 80 mg SiNPs were exposed to rats for 60 days. At the end of the exposure period serum were removed from the blood for the investigation of reproductive hormones such as Folicle stimulating Hormones (FSH), Leutinizing Hormones (LH), Testosterone (TT) and Prolactin (PROL) in both control and experimental rats. In the present study it was found that LH, FSH, Testosterone and Prolactin values significantly alters SiNPs exposed groups when compared with control groups. We also found that epididymal sperm count was decreased significantly in the experimental groups. On the basis of results it may be concluded that the interperitoneal injection of SiNPs alters the male reproductive hormones, which further deteriorate the spermatogenesis.