DOI: 10.21276/sasjs.2018.4.10.13

Pages: 224-230

Direct laryngoscopy and tracheal intubation predictably lead to tachyarrhythmia and hypertension which are usually transient and variable, but these may be fatal in high risk patients. These haemodynamic responses can be attenuated by variable premedication. Dexmedetomidine and clonidine, alpha 2 adrenergic agonist, might do so. The present study was aim to compare these drug for attenuation of haemodynamic response after laryngoscopy and intubation. Hundred adult patients of ASA grade I and II were randomly allocated into two groups of 50 each. We used either dexmedetomidine (group D) 0.5 mcg/kg or clonidine (group C) 3 mcg/kg I.V in 100 ml NS, 10 min before induction. We observed haemodynamic changes during laryngoscopy and intubation, sedation score and any side effects of drugs.