DOI: 10.36347/sjams.2021.v09i12.004

Pages: 1789-1793

Diabetes Mellitus (DM) denotes a group of metabolic disorders resulting from a multifaceted interaction of genetic and environmental factors that share the phenotype of hyperglycemia which when uncontrolled results in impaired lipid metabolism leading to an array of cardiovascular, cerebrovascular and other complication. International Diabetes Federation (IDF) estimates the global prevalence of diabetes to increase from 7.5% in 2019 to 8.0% in 2030 and 8.6% in 2045 with India ranking 2nd in top 10 countries with most number of people with diabetes contributing significantly to global disease burden. The present study was carried out with the aim of determining the increase in abnormal lipid profile among cases of diabetes compared to apparently healthy controls and to determine the presence or absence of association between abnormal blood glucose and dyslipidemia. The study comprised of 202 cases of type 2 diabetes mellitus (T2DM) and 202 apparently healthy controls all of whom underwent laboratory investigation using venous blood sampling to determine their serum glycated haemoglobin (HbA1c), Fasting blood sugar (FBS), Random blood sugar (RBS), total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL). The prevalence of abnormal lipid profile was greater in cases compared to controls with a significant correlation between poor glycemic control and dyslipidemia. This finding clearly indicates that patients with diabetes have a greater prevalence of dyslipidemia which had adverse effects on end organs especially the heat and brain. Thus optimal glycemic control is essential to control lipid dysfunction in diabetics hence leading to decreased morbidity.