DOI: 10.21276/sasjs.2018.4.11.10

Pages: 281-285

Postoperative intraabdominal adhesion (PIA) formation is an important cause of morbidity and mortality in patients undergoing abdominal surgery. This experimental study aims to evaluate the effects of Nigella sativa oil (NSO) on fibrinolytic system, while reducing PIA formation. A total of 16 Wistar Albino rats, each weighting 200 to 250 g, were used in this study. All rats were divided into two separate groups, as Group 1 (control group; n=8) and Group 2 (experimental group; n=8). An experimental adhesion model was formed in which Group 1 rats were administered with 1 mL isotonic saline intraabdominally, while Group 2 rats were administered with 1 mL NSO. The rats were sacrificed on postoperative day 10.Tissue plasminogen activator (tPA) concentration in the blood and peritoneal fluid was measured using the enzyme-linked immunosorbent assay (ELISA), and adhesion formation was evaluated using macroscopic and microscopic examinations.