DOI: 10.36347/sjams.2021.v09i12.012

Pages: 1846-1852

Background: Acute kidney injury leads the liver cirrhosis patients to the doom of multiorgan failure. The acute kidney injury diagnosis in the early possible period in the hospitalized cirrhotic patients can save many lives. But it is difficult to detect acute kidney injury early without conventional biochemical tool, serum creatinine. Abrupt increase of the level of serum creatinine by at least 0.3 mg/dL may be termed as acute kidney injury. It may occur in about 20% of hospitalized patients in decompensating liver cirrhosis. The commonest causes of acute kidney injury in cirrhotic patients are pre-renal azotemia, hepatorenal syndrome and acute tubular necrosis. Objective: The aim of this study was to assess of an increase urinary Neutrophil Gelatinase Associated Lipocalin level predicts the development of acute kidney injury in cirrhotic patients, to determine the accuracy of urinary Neutrophil Gelatinase Associated Lipocalin as a diagnostic marker of acute kidney injury in cirrhotic patients and to find out the cut off value of urinary Neutrophil Gelatinase Associated Lipocalin level to diagnose acute kidney injury in cirrhotic patients. Materials and methods: This was a cross sectional study at the department of hepatology, BSMMU, Dhaka, during September 2016 to April 2017. Total 70 hospitalized patients with decompensated cirrhosis & decompensated cirrhosis with AKI prone condition and who fulfilling the inclusion and exclusion criteria were included in this study. Patient with co-morbid condition (COPD, CKD, CCF etc.), history of pre-existing liver or kidney transplantation, hemodialysis and urinary tract obstruction were excluded from this study. Results: The mean age of the respondents was 43.49±12.46 years and 46.09±14.90 years in Group A and Group B respectively. Twenty six (74.3%) were male and 9 (25.7%) were female in Group A. Twenty seven (77.1%) were male and 8 (22.9%) were female in group B. Male patients were predominant in both groups. .............