DOI: 10.36347/sjams.2021.v09i12.016

Pages: 1867-1872

Introduction: Stroke is a leading cause of death and long-term disability worldwide. Of the total number of prevalent strokes, more than 80% are ischemic. Atherosclerosis being an inflammatory condition is associated with raised serum level of CRP. Hence the possible role of serum CRP in pathogenesis of AIS is being studied. Many studies support that serum CRP is a marker of stroke severity and prognosis. Materials and Methods: The observational and prospective study was carried out at Department of Neurology, Sheikh Sayera Khatun Medical College, Gopalganj, Bangladesh from January to December-2020.The present study ‘Serum C-reactive protein in Acute Ischemic stroke and its impact on stroke severity and prognosis. Total 51 neuroimaging confirmed cases of AIS were selected randomly for this non- interventional prospective study. Serum CRP was measured in all patients and NIHSSS was used for assessing stroke severity. Results: The mean CRP level was 21.93±3.60 mg/l and only 18% of cases were having normal CRP level. 60% of cases were having serum CRP level in the range of 3-30mg/L and 18% were having even the higher level. Age of the patient significantly correlated with the CRP level (r=0.294 at p-0.05) but the sex didn’t affect the rise in CRP (p= 0.490). Serum CRP level was affecting the stroke severity significantly (r=0.643, p-0.000).The mean CRP level in discharged patients was 10.51 ± 13.21 mg/l whereas it was 44.11 ± 29.7 mg/l in those who died in the hospital. Thus CRP level affected mortality of acute ischemic stroke significantly. (p-0.00). Conclusion: CRP is raised in most of the patients of acute ischemic stroke and its elevation reveals the underlying inflammation causing atherosclerosis as well as CRP as a marker of brain injury. Serum C-reactive protein elevation is associated with more severe stroke and poor prognosis.