DOI: 10.36347/sajb.2021.v09i12.004

Pages: 405-410

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin various proteins which are involved in major neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. The aim of the present study is to investigate sleep deprivation (SD) induced oxidative stress in different parts of the brain and in vivo behavioural changes associated with aging. Lipid peroxidation and reduced antioxidant status were significantly (p<0.05) increased along with the altered learning and memory ability. The most affected part of the brain was hippocampus followed by cerebral cortex. Acetyl cholinesterase was found to be altered in SD treated rats. These are remarkably correlated with the cognitive impairment. Aging is the affects more deleterious effect. It is also evident that SD induces premature aging in the study.