DOI: 10.36347/sasjs.2022.v08i01.007

Pages: 22-26

Menetrier’s disease (MD) is a rare hypertrophic gastropathy clinically characterized by digestive signs as epigastric pain, nausea, vomiting and diarrhea, with hypoalbuminemia and anemia, endoscopically by giant rugal folds and histologically by tortuous foveolar hyperplasia with dilated glands and hypertrophic muscularis mucosae. The current study presents a case of MD in 44 year-old-man admitted to the hospital of Hassan II in Fez, Morocco with epigastralgia, vomiting and weight loss. Physical examination fond a pale face and anemia in laboratory studies. A total gastrectomy was performed given the resistance to treatment and the persistence of symptoms, as well as the suspect endoscopic aspect. Macroscopic examination showed hypertrophic and polyploid gastric mucosa resembles cerebral convolutions. Histological examination showed a foveolar hyperplasia, tortuosity and dilatation of the glands. Hypertrophic muscularis mucosae with smooth muscle bundles extending into the lamina propria have also been observed. MD is considered as precancerous condition, and is associated with an increased risk of gastric cancer. This is a retrospective study of MD to describe his clinical, endoscopic and histological features, showing also the difficulty of the histological diagnosis.